1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt) (Synonyms: biotin-cap-DPPE)

1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1]  It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used in SLBs partitioned into nanowells to create DNA curtains, which can be used as a high-throughput tool for detection of protein-DNA interactions at the single molecule level.[3]

Reference:
[1]. Yeh, P.-Y., Chen, Y.-R., Wang, C.-F., et al. Promoting multivalent antibody-antigen interactions by tethering antibody molecules on a PEGylated dendrimer-supported lipid bilayer. Biomolecules 19(2), 426-437 (2018).
[2]. Jung, H., Robison, A.D., and Cremer, P.S. Detecting protein-ligand binding on supported bilayers by local pH modulation. J. Am. Chem. Soc. 131(3), 1006-1014 (2009).
[3]. Visnapuu, M.-L., Fazio, T., Wind, S., et al. Parallel arrays of geometric nanowells for assembling curtains of DNA with controlled lateral dispersion. Langmuir 24(19), 11293-11299 (2008).