1-Hydroxyanthraquinone (Synonyms: NSC 8640) |
| カタログ番号GC48909 |
1-ヒドロキシアントラキノンは、タベブイア・アベラネダエなどの一部の植物からの経口活性を持つ天然化合物で、発がん作用を示します。
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Cas No.: 129-43-1
Sample solution is provided at 25 µL, 10mM.
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1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities.1,2 1-Hydroxyanthraquinone (5 and 500 µM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity.1 Dietary administration of 1-hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats.
1.Kawai, K., Mori, H., Sugie, S., et al.Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinonesCell Biol. Toxicol.2(4)457-467(1986) 2.Mori, H., Yoshimi, N., Iwata, H., et al.Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasmsCarcinogenesis11(5)799-802(1990)
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