1-Lauroyl-rac-glycerol (Synonyms: MG(12:0/0:0/0:0), 1-Monolaurin, NSC 698570)

1-Lauroyl-rac-glycerol is a monoacylglycerol that contains lauric acid at the sn-1 position. It is active against pneumococci, group A streptococci, β-hemolytic non-group A streptococci, corynebacteria, N. asteroides, micrococci, S. aureus, S. epidermidis, and C. albicans (MICs = 0.045-0.09 μmol/ml).1 It is also active against a panel of 16 fungi when used at a concentration of 0.1% in growth media.2 Dietary administration of 1-lauroyl-rac-glycerol (2% w/w) reduces S. mutans colony forming units (CFUs) on tooth surfaces and severity of sucrose-induced dental caries in rats.3

|1. Kabara, J.J., Swieczkowski, D.M., Conley, A.J., et al. Fatty acids and derivatives as antimicrobial agents. Antimicrob. Agents Chemother. 2(1), 23-28 (1972).|2. Lisker, N., and Paster, N. Antifungal activity of monolaurin and related compounds. J. Food Saf. 4(1), 27-34 (1982).|3. Lynch, P., Kabara, J.J., and Schemmel, R. Streptococcus mutans colony forming units and severity of dental caries in rats fed three types of diets with and without Lauricidin. Microbios Lett. 12(45), 7-13 (1979).