ホーム>>Lipids>> Glycerophospholipids>>1-Oleyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

1-Oleyl-2-hydroxy-sn-glycero-3-PA (sodium salt) (Synonyms: LPA O-18:0; O-18:0 LPA; 1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate; 1-Octadecyl LPA; 1-Octadecyl Lysophosphatidic Acid; 1-Oleyl LPA; 1-Oleyl Lysophosphatidic Acid; PA(O-18:0/0:0))

カタログ番号GC91421

1-オレイル-2-ヒドロキシ-sn-グリセロ-3-PA(1-Octadecyl LPA)は、sn-1位置にステアリルアルコールを含むLPAアナログです。

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1-Oleyl-2-hydroxy-sn-glycero-3-PA (sodium salt) 化学構造

サイズ 価格 在庫数 個数
1mg
$57.00
在庫あり
5mg
$256.00
在庫あり
10mg
$451.00
在庫あり
25mg
$983.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of 1-Oleyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

1-Oleyl-2-hydroxy-sn-glycero-3-PA (1-Octadecyl LPA) is a LPA analog containing stearyl alcohol at the sn-1 position. LPA binds to one of five different G protein-linked receptors to mediate a variety of biological responses including cell proliferation, smooth muscle contraction, platelet aggregation, neurite retraction, and cell motility.1,2 Alkyl ether-linked LPA derivatives have a higher platelet aggregating activity than the acyl derivatives, most likely stemming from an alkyl-specific LPA receptor. For example, 1-octadecyl LPA has platelet aggregating activity with an EC50 value of 9 nM versus an EC50 value of 177 nM for 1-octadecanoyl LPA.3

Chemical Properties of 1-Oleyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

Cas No. SDF
同義語 LPA O-18:0; O-18:0 LPA; 1-Octadecyl-2-hydroxy-sn-glycero-3-phosphate; 1-Octadecyl LPA; 1-Octadecyl Lysophosphatidic Acid; 1-Oleyl LPA; 1-Oleyl Lysophosphatidic Acid; PA(O-18:0/0:0)
Formula C21H44O6P • Na M.Wt 446.5
溶解度 Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 1-Oleyl-2-hydroxy-sn-glycero-3-PA (sodium salt)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.2396 mL 11.1982 mL 22.3964 mL
5 mM 447.9 μL 2.2396 mL 4.4793 mL
10 mM 224 μL 1.1198 mL 2.2396 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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