10,11-dehydro Curvularin (Synonyms: α,β-dehydro Curvularin) |
| カタログ番号GC41863 |
10,11-デヒドロ クルブラリンは、一般的な真菌の植物毒であり、抗生物質です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 21178-57-4
Sample solution is provided at 25 µL, 10mM.
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10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response, a conserved evolutionary mechanism that maintains protein homeostasis via the overexpression of heat shock factor 1 (HSF1) and various chaperones including heat shock protein 90 (Hsp90). 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].
References:
[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.
[2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.
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