10-acetyl Docetaxel (Synonyms: PNU 101383, 10-acetyl Taxotere) |
カタログ番号GC49736 |
10-アセチル ドセタキセル (10-アセチル ドセタキセル) は、抗がん作用を持つドセタキセルの類似体です。ドセタキセルは、抗有糸分裂活性を持つ微小管分解阻害剤です。
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Cas No.: 125354-16-7
Sample solution is provided at 25 µL, 10mM.
10-acetyl Docetaxel is a derivative of paclitaxel and an inhibitor of microtubule depolymerization.1 It inhibits calcium-induced depolymerization of calf brain microtubule protein (MTP) in a cell-free assay when used at 20 µM. 10-acetyl Docetaxel is cytotoxic to J774.2 cells (EC50 = 0.05 µM).
1.Swindell, C.S., Heerding, J.M., Krauss, N.E., et al.Characterization of the taxol structure-activity profile for the locus of the A-ring side chainBioorg. Med. Chem. Lett.4(12)1531-1536(1994)
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