12-Bromododecanoic Acid (Synonyms: 12-Bromo-C12:0, 12-Bromododecanoate, 12-Bromolauric Acid, NSC 660375) |
| カタログ番号GC46415 |
ラウリン酸のハロゲン化形態
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 73367-80-3
Sample solution is provided at 25 µL, 10mM.
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12-Bromododecanoic acid is a halogenated form of lauric acid . It has been used in the synthesis of clickable forms of myristic acid and as a model fatty acid ligand to determine the X-ray crystal structure of bovine β-lactoglobulin-ligand complexes.1,2 12-Bromododecanoic acid (10 µg/ml) reduces virion DNA in the culture supernatant of primary hepatocytes isolated from a duckling model of hepatitis B virus (HBV) infection and inhibits HIV replication in CEM-SS T cells (EC50 = 38 µM).3
1.Heal, W.P., Wickramasinghe, S.R., Leatherbarrow, R.J., et al.N-Myristoyl transferase-mediated protein labelling in vivoOrg. Biomol. Chem.6(13)2308-2315(2008) 2.Qin, B.Y., Creamer, L.K., Baker, E.N., et al.12-Bromododecanoic acid binds inside the calyx of bovine β-lactoglobulinFEBS Lett.438(3)272-278(1998) 3.Parang, K., Wiebe, L.I., Knaus, E.E., et al.In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis B virusesAntiviral Res.34(3)75-90(1997)
| Cas No. | 73367-80-3 | SDF | |
| 同義語 | 12-Bromo-C12:0, 12-Bromododecanoate, 12-Bromolauric Acid, NSC 660375 | ||
| Canonical SMILES | BrCCCCCCCCCCCC(O)=O | ||
| Formula | C12H23BrO2 | M.Wt | 279.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.5817 mL | 17.9083 mL | 35.8166 mL |
| 5 mM | 0.7163 mL | 3.5817 mL | 7.1633 mL |
| 10 mM | 0.3582 mL | 1.7908 mL | 3.5817 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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