12(S)-HETE (Synonyms: 12(S)-Hydroxyeicosatetraenoic Acid) |
| カタログ番号GC40448 |
12(S)-HETEは哺乳動物の血小板におけるリポキシゲナーゼ生成物の主要なものです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 54397-83-0
Sample solution is provided at 25 µL, 10mM.
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12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. [1] It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1µM181M.[2][3]
Reference:
[1]. Hamberg, M., and Samuelsson, B. Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc. Natl. Acad. Sci. U.S.A. 71(9), 3400-3404 (1974).
[2]. Grossi, I.M., Fitzgerald, L.A., Umbarger, L.A., et al. Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid. Cancer Res. 49(4), 1029-1037 (1989).
[3]. Honn, K.V., Nelson, K.K., Renaud, C., et al. Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis. Prostaglandins 44(5), 413-429 (1992).
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