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17β-hydroxy Exemestane

カタログ番号GC41300

17β-ヒドロキシエキセメスタンは、エキセメスタンの主要な活性代謝物です。

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17β-hydroxy Exemestane 化学構造

Cas No.: 122370-91-6

サイズ 価格 在庫数 個数
1mg
$369.00
在庫あり
5mg
$1,198.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

17β-ヒドロキシエキセメスタンは、エキセメスタンの主要な活性代謝物質です。これは、サイトクロムP450(CYP)アイソフォームCYP1AおよびCYP4A11によるエキセメスタンの代謝によって形成されます。 17β-ヒドロキシエキセメスタンは、人間胎盤微小体を用いた場合の芳香族化酵素阻害剤(IC50 = 69 nM)であり、アンドロゲン受容体(AR)アゴニスト(IC50 = 39.6 nM)でもありますが、ERαに対して選択的であることが示されています。(ERα; IC50 = 21.2 μM)。 AR陽性およびERα陽性のMCF-7細胞(EC50 = 2.7μM)、T47D乳癌細胞(AR介在増殖:EC50s=0.43nM; ER介在増殖:1500nM) の成長を刺激し、テストステロン処理下で芳香族化酵素過剰発現する MCF-7aro 細胞の増殖を濃度依存的に抑制します。また、17β-ヒドロキシエキセメスタン(20 mg/kg)は、去勢ラットにおいて血清コレステロールおよびLDL値の上昇を抑制し、腰椎骨密度や大腿骨、第5腰椎の屈曲強度と圧縮強度の低下を防止します。

Chemical Properties

Cas No. 122370-91-6 SDF
Canonical SMILES C=C1C2=CC(C=C[C@]2(C)[C@]3([H])[C@@]([C@@](CC[C@@H]4O)([H])[C@]4(C)CC3)([H])C1)=O
Formula C20H26O2 M.Wt 298.4
溶解度 Chloroform: slightly, heated,Methanol: slightly, heated Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.3512 mL 16.756 mL 33.5121 mL
5 mM 0.6702 mL 3.3512 mL 6.7024 mL
10 mM 0.3351 mL 1.6756 mL 3.3512 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Average Rating: 5 ★★★★★ (Based on Reviews and 9 reference(s) in Google Scholar.)

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