17β-hydroxy Wortmannin |
| カタログ番号GC41979 |
17β-ヒドロキシワートマニンは、ワートマニンのアナログです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 58053-83-1
Sample solution is provided at 25 µL, 10mM.
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17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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