ホーム>>Lipids>> Hydroxy/Hydroperoxy/Epoxy/Oxo Eicosanoids>>(±)14(15)-DiHET-d11

(±)14(15)-DiHET-d11 (Synonyms: (±)14,15-DiHETrE-d11)

カタログ番号GC46258

多様な生物学的活性を持つ神経ペプチド

Products are for research use only. Not for human use. We do not sell to patients.

(±)14(15)-DiHET-d11 化学構造

Cas No.: N/A

サイズ 価格 在庫数 個数
25 μg
$255.00
在庫あり
50 μg
$482.00
在庫あり
100 μg
$914.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com


顧客レビュー

カスタマーレビューに基づきます。

Sample solution is provided at 25 µL, 10mM.

Description of (±)14(15)-DiHET-d11

(±)14(15)-DiHET-d11 contains 11 deuterium atoms at the 16, 16, 17, 17, 18, 18, 19, 19, 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)14(15)-DiHET by GC- or LC-mass spectrometry. Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.1 (±)14(15)-DiHET is the urinary metabolite of (±)14(15)-EET which has been documented by GC-MS to be elevated in pregnancy-induced hypertension.2

1.Oliw, E.H., Guengerich, F.P., and Oates, J.A.Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediatesJ. Biol. Chem.257(7)3771-3781(1982) 2.Catella, F., Lawson, J.A., Fitzgerald, D.J., et al.Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertensionProc. Natl. Acad. Sci. U.S.A.87(15)5893-5897(1990)

Chemical Properties of (±)14(15)-DiHET-d11

Cas No. N/A SDF
同義語 (±)14,15-DiHETrE-d11
Canonical SMILES O[C@H]([C@H](O)C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C/C=C\C/C=C\C/C=C\CCCC(O)=O
Formula C20H23D11O4 M.Wt 349.6
溶解度 DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 0.5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (±)14(15)-DiHET-d11

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.8604 mL 14.3021 mL 28.6041 mL
5 mM 572.1 μL 2.8604 mL 5.7208 mL
10 mM 286 μL 1.4302 mL 2.8604 mL
  • モルアリティ計算機

  • 希釈計算機

  • Molecular Weight Calculator

質量
=
濃度
x
容積
x
MW*
 
 
 
**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

In vivo Formulation Calculator (Clear solution) of (±)14(15)-DiHET-d11

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

View current batch:

レビュー

Review for (±)14(15)-DiHET-d11

Average Rating: 5 ★★★★★ (Based on Reviews and 24 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for (±)14(15)-DiHET-d11

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.