ホーム>>Analytical Standards>>(±)5(6)-DiHET

(±)5(6)-DiHET (Synonyms: (±)5,6-DiHETrE)

カタログ番号GC40270

5(6)-DiHETは、エポキシドヒドロラーゼによって生合成された対向異性体形態の完全なラセミ体です。

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(±)5(6)-DiHET 化学構造

Cas No.: 213382-49-1

サイズ 価格 在庫数 個数
25μg
$127.00
在庫あり
50μg
$241.00
在庫あり
100μg
$455.00
在庫あり
250μg
$1,015.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

5(6)-DiHETは、エポキシドヒドロラーゼによって生合成された対映異性体形態の完全なラセミ体です。[1] 5(6)-EETからの変換により、5(6)-EETを定量するために使用できます。[2] 5(6)-DiHETは、ラット小冠動脈平滑筋細胞内の大型伝導カルシウム活性化カリウム(BK)チャネルを活性化します。[3] 羊精嚢COXの基質としても機能し、in vitroでは5,6-ジヒドロキシプロスタグランジンE1およびF1α代謝物を生成します。[4] また、高脂肪食誘発性ラットモデルの血漿中で5(6)-DiHETレベルが低下することが報告されています。[5]

参考文献:
[1]. Oliw, E.H., Guengerich, F.P., and Oates, J.A. Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. J. Biol. Chem. 257(7), 3771-3781 (1982).
[2]. Rashid, M., Manivet, P., Nishio, H., et al. Identification of the binding sites and selectivity of sarpogrelate, a novel 5-HT2 antagonist, to human 5-HT2A, 5-HT2B and 5-HT2C receptor subtypes by molecular modeling. Life Sci. 73(2), 193-207 (2003).
[3]. Lu,T、Katakam,P.V.G、VanRollins,M、et al.Dihydroxyeicosatrienoic acids are potent activators of Ca^2+-activated K^+ channels in isolated rat coronary arterial myocytes.J.Physiol.534(Pt3)、651-667(2001)。
[4].Oliw,E.H.Biosynthesisof5,6-dihydroxyprostaglandinE1andF1αfrom5,6-dihydroxyeicosatrienoicacidbyramseminalvesicles.Biochim.Biophys.Acta。795(2)、384-391(1984)。
[5]。Miao,H.Zhao,Y.-H.Vaziri,N.D.et al.Lipidomicsbiomarkersofdiet-inducedhyperlipidemiaanditstreatmentwithPoriacocos.J.Agric.FoodChem。64(4)、969-979(2016)。

Chemical Properties

Cas No. 213382-49-1 SDF
同義語 (±)5,6-DiHETrE
Chemical Name (±)5,6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid
Canonical SMILES CCCCC/C=C\C/C=C\C/C=C\C[C@@H](O)[C@@H](O)CCCC(O)=O
Formula C20H34O4 M.Wt 338.5
溶解度 50mg/mL in DMSO, 50mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9542 mL 14.771 mL 29.5421 mL
5 mM 0.5908 mL 2.9542 mL 5.9084 mL
10 mM 0.2954 mL 1.4771 mL 2.9542 mL
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Review for (±)5(6)-DiHET

Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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