(±)9(10)-DiHOME (Synonyms: Leukotoxin diol) |
| カタログ番号GC40801 |
(±)9(10)-DiHOME は 9,10-DiHOME のラセミ体です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 263399-34-4
Sample solution is provided at 25 µL, 10mM.
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Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst. This unstable compound is rapidly degraded by epoxide hydrolases to form the diol, (±)9(10)-DiHOME. Mitochondrial dysfunction, vasodilation, and apoptosis are features of leukotoxin toxicity. In renal proximal tubular cells, the diol hydrolysis products of leukotoxin, such as (±)9(10)-DiHOME, have been directly implicated as the cytotoxic agent responsible for cell death.
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