(±)-MMT5-14 |
カタログ番号GC52224 |
抗ウイルス活性を持つレムデシビルの誘導体
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2719679-31-7
Sample solution is provided at 25 µL, 10mM.
(±)-MMT5-14 is a derivative of remdesivir with antiviral activity.1 It increases the viability of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC50 = 0.4 µM), as well as Vero E6 cells infected with the Alpha, Beta, Gamma, or Delta SARS-CoV-2 variants (EC50s = 2.5, 15.9, 1.7, and 5.6 µM, respectively). (±)-MMT5-14 exhibits increased plasma and lung concentrations compared with remdesivir in hamsters when administered at a dose of 10 mg/kg.
1.Hu, H., Traore, M.D.M., Li, R., et al.Optimization of the prodrug moiety of remdesivir to improve lung exposure/selectivity and enhance anti-SARS-CoV-2 activityJ. Med. Chem.65(18)12044-12054(2022)
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