ホーム>>Signaling Pathways>> Membrane Transporter/Ion Channel>>(±)-Nornicotine-d4

(±)-Nornicotine-d4 (Synonyms: DL-Nornicotine-d4, (R,S)-Nornicotine-d4)

カタログ番号GC49482

(±)-ノルニコチンの定量化のための内部標準

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(±)-Nornicotine-d4 化学構造

Cas No.: 66148-18-3

サイズ 価格 在庫数 個数
1 mg
$43.00
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5 mg
$195.00
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10 mg
$334.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

(±)-ノルニコチン-d4は、GCまたはLC-MSによる(±)-ノルニコチンの定量化のための内部標準として使用することを意図しています。 (±)-ノルニコチンは、ニコチンの活性代謝物質であり、ニコチン性アセチルコリン受容体(nAChR)アゴニストです。1 それは、人間α7 nAChRsまたはα6サブユニット含有nAChRsを発現するXenopus oocytesで電流を誘導します(EC50値=それぞれ17および3.7μM)。 (±)-ノルニコチンはEA.hy926内皮細胞で細胞移動を促進し、細胞間接続を不安定にします。2 ラットでは自己投与されます。3,4

1. Papke, R.L., Dwoskin, L.P., and Crooks, P.A. ニコチンとノルニコチンのnAChRサブタイプに対する薬理活性:ニコチン依存症および薬剤探索に関連。J. Neurochem. 101(1)160-167(2007年) 2. Gagat、M.、Grzanka、D.、Izdebska、M。など。NornicotineはEA.hy926細胞株で内皮細胞間接着点複合体を損傷させることがF-actinの構造再編成を介して示された。Folia Histochem.Cytobiol.51(3)179-192(2013年) 3.Bardo,M.T.,Green,T.A.,Crooks,P.A。,など。ラットによって静脈内自己投与されるノルニコチンPsychopharmacology(Berl)146(3)290-296(1999) 4.Hoffman,A.C.and Evans,S.E.Non-nicotine tobacco smoke components:Acetaldehyde,nornicotine,cotinine,and anabasineの乱用ポテンシャルNicotine Tob.Res15(3)622-632(2013)

Chemical Properties

Cas No. 66148-18-3 SDF Download SDF
同義語 DL-Nornicotine-d4, (R,S)-Nornicotine-d4
Canonical SMILES [2H]C1=NC([2H])=C(C2NCCC2)C([2H])=C1[2H]
Formula C9H8D4N2 M.Wt 152.2
溶解度 Methanol: soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 6.5703 mL 32.8515 mL 65.703 mL
5 mM 1.3141 mL 6.5703 mL 13.1406 mL
10 mM 0.657 mL 3.2852 mL 6.5703 mL
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Review for (±)-Nornicotine-d4

Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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