(±)-Nornicotine-d4 (Synonyms: DL-Nornicotine-d4, (R,S)-Nornicotine-d4) |
カタログ番号GC49482 |
(±)-ノルニコチンの定量化のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 66148-18-3
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(±)-ノルニコチン-d4は、GCまたはLC-MSによる(±)-ノルニコチンの定量化のための内部標準として使用することを意図しています。 (±)-ノルニコチンは、ニコチンの活性代謝物質であり、ニコチン性アセチルコリン受容体(nAChR)アゴニストです。1 それは、人間α7 nAChRsまたはα6サブユニット含有nAChRsを発現するXenopus oocytesで電流を誘導します(EC50値=それぞれ17および3.7μM)。 (±)-ノルニコチンはEA.hy926内皮細胞で細胞移動を促進し、細胞間接続を不安定にします。2 ラットでは自己投与されます。3,4
1. Papke, R.L., Dwoskin, L.P., and Crooks, P.A. ニコチンとノルニコチンのnAChRサブタイプに対する薬理活性:ニコチン依存症および薬剤探索に関連。J. Neurochem. 101(1)160-167(2007年) 2. Gagat、M.、Grzanka、D.、Izdebska、M。など。NornicotineはEA.hy926細胞株で内皮細胞間接着点複合体を損傷させることがF-actinの構造再編成を介して示された。Folia Histochem.Cytobiol.51(3)179-192(2013年) 3.Bardo,M.T.,Green,T.A.,Crooks,P.A。,など。ラットによって静脈内自己投与されるノルニコチンPsychopharmacology(Berl)146(3)290-296(1999) 4.Hoffman,A.C.and Evans,S.E.Non-nicotine tobacco smoke components:Acetaldehyde,nornicotine,cotinine,and anabasineの乱用ポテンシャルNicotine Tob.Res15(3)622-632(2013)
Cas No. | 66148-18-3 | SDF | Download SDF |
同義語 | DL-Nornicotine-d4, (R,S)-Nornicotine-d4 | ||
Canonical SMILES | [2H]C1=NC([2H])=C(C2NCCC2)C([2H])=C1[2H] | ||
Formula | C9H8D4N2 | M.Wt | 152.2 |
溶解度 | Methanol: soluble | Storage | -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 6.5703 mL | 32.8515 mL | 65.703 mL |
5 mM | 1.3141 mL | 6.5703 mL | 13.1406 mL |
10 mM | 0.657 mL | 3.2852 mL | 6.5703 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 13 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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