(±)-Nornicotine (Synonyms: DL-Nornicotine, (R,S)-Nornicotine) |
カタログ番号GC41676 |
(±)-ノルニコチンは、神経ニコチン性アセチルコリン受容体(nAChR)アゴニストとして作用するニコチンの代謝物です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5746-86-1
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
(±)?ノルニコチンは、神経ニコチン性アセチルコリン受容体(nAChR)アゴニストとして作用するニコチンの代謝物です。α6およびα7サブユニットを含む神経nAChRは、Xenopus oocytesで発現した場合、約4および17 µMのEC50値で特にノルニコチンに反応します。ノルニコチンは内皮細胞株において細胞移動を促進し、細胞間接着点を不安定化させます。一般的に乱用の可能性がないと考えられていますが、ラットによって自己投与されたことがあります。尿中でも検出されることがあります。
Cas No. | 5746-86-1 | SDF | |
同義語 | DL-Nornicotine, (R,S)-Nornicotine | ||
Canonical SMILES | C1(C2CCCN2)=CC=CN=C1 | ||
Formula | C9H12N2 | M.Wt | 148.2 |
溶解度 | DMF: 50 mg/ml,DMSO: 30 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml | Storage | Store at 2-8°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 6.7476 mL | 33.7382 mL | 67.4764 mL |
5 mM | 1.3495 mL | 6.7476 mL | 13.4953 mL |
10 mM | 0.6748 mL | 3.3738 mL | 6.7476 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 34 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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