19-O-Acetylchaetoglobosin A (Synonyms: Chaetoglobosin A Acetate) |
| カタログ番号GC48423 |
サイトカラサン アルカロイドである 19-O-アセチルケトグロボシン A は、もともと C. globosum から分離された真菌代謝産物であり、アクチン重合阻害および細胞毒性活性を持っています。 19-O-アセチルケトグロボシン A は、HeLa 子宮頸がん細胞に対して細胞毒性を示します。
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Cas No.: 50939-69-0
Sample solution is provided at 25 µL, 10mM.
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19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated from C. globosum that has actin polymerization inhibitory and cytotoxic activities.1,2 It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 µM.2 19-O-Acetylchaetoglobosin A (3.2, 10, and 32 µg/ml) is cytotoxic to HeLa cervical cancer cells.1
1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)
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