1G244 |
| カタログ番号GC39296 |
1G244 は、それぞれ 12 nM および 84 nM の IC50 を持つ強力な DPP8/9 阻害剤です。 1G244 は DPPIV および DPPII を阻害しません。 1G244 は多発性骨髄腫細胞のアポトーシスを誘導し、抗骨髄腫効果があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 847928-32-9
Sample solution is provided at 25 µL, 10mM.
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1G244 is a potent DPP8/9 inhibitor with IC50s of 12 nM and 84 nM, respectively. 1G244 does not inhibit DPPIV and DPPII. 1G244 induces apoptosis in multiple myeloma cells and has anti-myeloma effects[1][2].
[1]. Sato T, et al. DPP8 is a novel therapeutic target for multiple myeloma. Sci Rep. 2019 Dec 2;9(1):18094. [2]. Leen Heirbaut, et al. Probing for improved selectivity with dipeptidederived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. MedChemComm. 2016, 7.
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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