2'-Deoxy-L-adenosine |
| カタログ番号GC67328 |
2'-デオキシ-L-アデノシンは、修飾オリゴデオキシリボヌクレオチドの経口活性シントンです。 2'-デオキシ-L-アデノシンは、B 型肝炎ウイルス (HBV) および密接に関連するアヒルおよびウッドチャック肝炎ウイルス (WHV) の複製の強力で特異的かつ選択的な阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14365-45-8
Sample solution is provided at 25 µL, 10mM.
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2'-Deoxy-L-adenosine is an orally active synthon for modified oligodeoxyribonucleotides. 2'-Deoxy-L-adenosine is a potent, specific and selective inhibitor of the replication of hepatitis B virus (HBV) as well as the closely related duck and woodchuck hepatitis viruses (WHV)[1].
2'-Deoxy-L-adenosine shows anti-hepadnavirus activity, withour affecting the replication of 15 other RNA and DNA viruses, neither nor inhibiting human DNA polymerases (α, β, and γ) or compromise mitochondrial function[1].
2'-Deoxy-L-adenosine (p.o.; once daily) reduces viral load by as much as 108 genome equivalent/mL serum without drug-related toxicity in woodchuck efficacy model of chronic HBV infection[1].
[1]. Standring DN, et al. Antiviral beta-L-nucleosides specific for hepatitis B virus infection. Antivir Chem Chemother. 2001;12 Suppl 1:119-29.
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