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2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline (Synonyms: MeIQx)

カタログ番号GC49362

食品由来の発がん物質

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2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline 化学構造

Cas No.: 77500-04-0

サイズ 価格 在庫数 個数
5 mg
$94.00
在庫あり
10 mg
$180.00
在庫あり
25 mg
$401.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

2-アミノ-3,8-ジメチルイミダゾ-[4,5-f]-キノキサリン(MeIQx)は、高温で調理された魚や肉に含まれる食物由来の発がん物質です。1 これは、シトクロムP450(CYP)アイソフォームCYP1A2およびN-アセチルトランスフェラーゼ2を介してUV5細胞において人間の酵素を発現させた場合に加水分解と後続のO-アセチル化によって活性化され、DNAと反応して付加体を形成する代謝産物になります。2 MeIQx(食事中の200 ppmおよび400 ppm)はラットで腫瘍形成を引き起こします。3

1. ヨハンソン、M.A.、およびイェーガースタッド、M.。家庭内条件下で調理された肉および魚製品(パンの残りを含む)における発がん性ヘテロ環式アミンの突然変異原性/発生Carcinogenesis15(8)1511-1518(1994) 2. Metry、K.J.、Neale、J.R.、Doll、M.A.など。急速な人間N-アセチルトランスフェラーゼ2ハプロタイプが2-アミノ-3-メチルイミダゾ-[4,5-f]キノリン(IQ)および2-アミノ-3,8-ジメチルイミダゾ-[4,5-f]キサントイン(MeIQx)によって誘導されるDNA損傷と突然変異に及ぼす影響Mutat.Res 684(1–2)66–73 (2010) 3.Kushida,H.,Wakabayashi,K.,Sato,H.,et al.MeIQxカルシノジェニシティのF344雄ラットにおける投与量反応関係研究Cancer Lett 83(1–2)31–35 (1994)

Chemical Properties

Cas No. 77500-04-0 SDF
同義語 MeIQx
Canonical SMILES NC(N1C)=NC2=C1C=CC3=NC=C(C)N=C32
Formula C11H11N5 M.Wt 213.2
溶解度 DMSO: slightly soluble,Methanol: slightly soluble Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.6904 mL 23.4522 mL 46.9043 mL
5 mM 0.9381 mL 4.6904 mL 9.3809 mL
10 mM 0.469 mL 2.3452 mL 4.6904 mL
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計算

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for 2-Amino-3,8-dimethylimidazo-[4,5-f]-quinoxaline

Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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