2-Nonylquinolin-4(1H)-one-d4 (Synonyms: 2-n-Nonyl-4-quinolone-d4, 2-Nonyl-1H-quinolin-4-one-d4, 2-Nonylquinolin-4(1H)-one-d4, Pseudane IX-d4) |
| カタログ番号GC52446 |
2-ノニルキノリン-4（1H）-oneの定量のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
2-Nonylquinolin-4(1H)-one-d4 is intended for use as an internal standard for the quantification of 2-nonylquinolin-4(1H)-one by GC- or LC-MS. 2-Nonylquinolin-4(1H)-one is a quinolone alkaloid that has been found in P. aeruginosa and has diverse biological activities.1,2,3,4 It reduces infection of Huh7.5 cells by hepatitis C virus (HCV) with an IC50 value of 1.4 µg/ml.1 2-Nonylquinolin-4(1H)-one (50 and 100 µg/ml) is also active against L. gongylophorus, a symbiotic fungus of the agricultural pest A. sexdens (leaf-cutting ant).2 It inhibits activation of nuclear factor of activated T cells (NFAT) induced by phorbol 12-myristate 13-acetate and the calcium ionophore A23187 in Jurkat cells (IC50 = 3.44 µM), but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50 = >100 µM), in reporter assays.3
1.Wahyuni, T.S., Widyawaruyanti, A., Lusida, M.I., et al.Inhibition of hepatitis C virus replication by chalepin and pseudane IX isolated from Ruta angustifolia leavesFitoterapia99276-283(2014) 2.Biavatti, M.W., Vieira, P.C., da Silva, F.d.G.F., et al.Biological activity of quinoline alkaloids from Raulinoa echinata and x-ray structure of flindersiamineJ. Braz. Chem. Soc.13(1)66-70(2002) 3.Jin, H.Z., Lee, J.H., Lee, D., et al.Quinolone alkaloids with inhibitory activity against nuclear factor of activated T cells from the fruits of Evodia rutaecarpaBiol. Pharm. Bull.27(6)926-928(2004) 4.Ortori, C.A., Dubern, J.-F., Chhabra, S.R., et al.Simultaneous quantitative profiling of N-acyl-L-homoserine lactone and 2-alkyl-4(1H)-quinolone families of quorum-sensing signaling molecules using LC-MS/MSAnal. Bioanal. Chem.399(2)839-850(2011)
| Cas No. | SDF | ||
| 同義語 | 2-n-Nonyl-4-quinolone-d4, 2-Nonyl-1H-quinolin-4-one-d4, 2-Nonylquinolin-4(1H)-one-d4, Pseudane IX-d4 | ||
| Canonical SMILES | O=C1C=C(CCCCCCCCC)NC2=C1C([2H])=C([2H])C([2H])=C2[2H] | ||
| Formula | C18H21D4NO | M.Wt | 275.4 |
| 溶解度 | DMF: 30 mg/mL,DMSO: 15 mg/mL,Ethanol: 30 mg/mL | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.6311 mL | 18.1554 mL | 36.3108 mL |
| 5 mM | 0.7262 mL | 3.6311 mL | 7.2622 mL |
| 10 mM | 0.3631 mL | 1.8155 mL | 3.6311 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *