(±)-2-propyl-4-Pentenoic Acid (Synonyms: 2-Allylpentanoic Acid, 4-ene VPA ) |
| カタログ番号GC18596 |
(±)-2-プロピル-4-ペンテン酸 (4-en-VPA) は、バルプロ酸の主要な毒性代謝物です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1575-72-0
Sample solution is provided at 25 µL, 10mM.
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(±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid.[1] It undergoes β-oxidation to form reactive metabolites that induce hepatotoxicity in rats. 4-ene VPA is also neuroteratogenic, reducing forebrain size and inducing deformation of the neural tube in mouse embryos.[2]
Reference:
[1]. Tang, W., and Abbott, F.S. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its α-fluorinated analogue: Phase II metabolism and pharmacokinetics. Drug Metab. Dispos. 25(2), 219-227 (1997).
[2]. Gofflot, F., Nassogne, M.C., Etzion, T., et al. In vitro neuroteratogenicity of valproic acid and 4-en-VPA. Neurotoxicol. Teratol. 17(4), 425-435 (1995).
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