2H-Cho-Arg (trifluoroacetate salt) |
| カタログ番号GC42161 |
2H-Cho-Argは、L-アルギニンヘッドグループに結合した2Hコレステロール骨格を含むステロイド系カチオン性リピッドであり、遺伝子トランスフェクションを促進するために使用されることがあります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1609010-59-4
Sample solution is provided at 25 µL, 10mM.
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2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein , but not by inhibitors of clathrin- or micropinocytosis-mediated endocytosis. It induces cytotoxicity in H1299 cells (IC50 = 92.7 μg/ml).
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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