(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) (Synonyms: (2R)Octyl2-HG) |
| カタログ番号GC32754 |
(2R)-オクチル-&α;-ヒドロキシグルタレート ((2R)-オクチル-2-HG) ((2R)-オクチル-2-HG) は、D-異性体 2-ヒドロキシグルタレートの修飾型です。
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Cas No.: 1391194-67-4
Sample solution is provided at 25 µL, 10mM.
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(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.
Treatment of IDH1-WT HeLa cells with (2R)-Octyl-α-hydroxyglutarate, a modified form of 2-Hydroxyglutarate with high cellular uptake, results in a dose-dependent increase in DSBs in log-phase cells. It has been used to examine the contribution of D-2-Hydroxyglutarate to the oxidative mitochondrial processes of IDH1-mutated cancer cells[1].
[1]. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).
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