3-Aminoisobutyric Acid (sodium salt) (Synonyms: β-Aminoisobutyric Acid, BAIBA) |
| カタログ番号GC46584 |
多様な生物学的活性を持つ神経ペプチド
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Cas No.: 84796-61-2
Sample solution is provided at 25 µL, 10mM.
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3-Aminoisobutyric acid is a non-protein amino acid formed during thymine catabolism.1 It induces browning in primary adipocytes, increasing the expression of uncoupling protein 1 (UCP-1) and CIDEA when used at a concentration of 5 µM. It also increases the expression of PPARα in primary adipocytes and in mouse inguinal white adipose tissue (WAT) in vivo and increases β-oxidation in hepatocytes. Plasma levels of 3-aminoisobutyric acid are increased in mice following exercise and, when administered at a dose of 100 mg/kg per day, it decreases weight gain and body fat percentage without decreasing food intake or increasing energy expenditure, and improves glucose tolerance. Levels of 3-aminoisobutyric acid are elevated in the plasma, urine, and cerebrospinal fluid of patients with β-ureidopropionase deficiency, a disorder characterized by an inborn error of pyrimidine degradation.2
1.Roberts, L.D., BostrÖm, P., O'Sullivan, J.F., et al.β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factorsCell Metab.19(1)96-108(2014) 2.van Kuilenburg, A.B., Meinsma, R., Beke, E., et al.β-Ureidopropionase deficiency: An inborn error of pyrimidine degradation associated with neurological abnormalitiesHum. Mol. Genet.13(22)2793-2801(2004)
| Cas No. | 84796-61-2 | SDF | |
| 同義語 | β-Aminoisobutyric Acid, BAIBA | ||
| Canonical SMILES | NCC(C)C(O)=O | ||
| Formula | C4H8NO2.Na | M.Wt | 125.1 |
| 溶解度 | DMSO: 10 mM | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 7.9936 mL | 39.968 mL | 79.9361 mL |
| 5 mM | 1.5987 mL | 7.9936 mL | 15.9872 mL |
| 10 mM | 0.7994 mL | 3.9968 mL | 7.9936 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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