3-Deazauridine (Synonyms: NSC 126849) |
| カタログ番号GC42260 |
3-デアザウリジンはヌクレオシドアナログです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 23205-42-7
Sample solution is provided at 25 µL, 10mM.
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3-Deazauridine is a nucleoside analog. [1] It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.[2] It also enhances the incorporation of decitabine into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.[3]
Reference:
[1]. Moriconi, W.J., Slavik, M., and Taylor, S. 3-Deazauridine (NSC 126849): An interesting modulator of biochemical response. Invest New Drugs 4(1), 67-84 (1986).
[2]. Bloch, A., Dutschman, G., Currie, B.L., et al. Preparation and biological activity of various 3-deazapyrimidines and related nucleosides. J. Med. Chem. 16(3), 294-297 (1973).
[3]. Raynal, N.J.-M., Momparler, L.F., Rivard, G.E., et al. 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase. Leuk. Res. 35(1), 110-118 (2011).
| Cas No. | 23205-42-7 | SDF | |
| 同義語 | NSC 126849 | ||
| Chemical Name | 4-hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone | ||
| Canonical SMILES | O=C(C=C(O)C=C1)N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2 | ||
| Formula | C10H13NO6 | M.Wt | 243.2 |
| 溶解度 | 10mg/mL in DMSO, 16mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.1118 mL | 20.5592 mL | 41.1184 mL |
| 5 mM | 822.4 μL | 4.1118 mL | 8.2237 mL |
| 10 mM | 411.2 μL | 2.0559 mL | 4.1118 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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