ホーム>>Nucleotides/Nucleosides>>3-Deazauridine

3-Deazauridine (Synonyms: NSC 126849)

カタログ番号GC42260

3-デアザウリジンはヌクレオシドアナログです。

Products are for research use only. Not for human use. We do not sell to patients.

3-Deazauridine 化学構造

Cas No.: 23205-42-7

サイズ 価格 在庫数 個数
5mg
$24.00
在庫あり
10mg
$46.00
在庫あり
25mg
$93.00
在庫あり
50mg
$148.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

顧客レビュー

カスタマーレビューに基づきます。

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

3-デアザウリジンは、ヌクレオシドアナログです。[1]細胞内で3-デアザウリジントリリン酸に変換され、シチジン三リン酸合成酵素を競争的に阻害するため、核酸シチジン5'-トリリン酸(CTP)の生合成を抑制します。 6μMの濃度で使用するとL1210白血病細胞の増殖を抑制し、マウス白血病モデルでは用量依存性に死亡率を減少させます。[2]また、20μMの濃度で使用するとHL-60系列およびMOLT-3系列白血病細胞中のDNAへのデシタビン取り込みが増加します。 L1210白血病マウスモデルでは、3-デアザウリジン(100または150 mg / kg)とデシタビンを併用することで死亡率が減少します。[3]

参考文献:
[1]. Moriconi, W.J., Slavik, M., and Taylor, S. 3-Deazauridine (NSC 126849): An interesting modulator of biochemical response. Invest New Drugs 4(1), 67-84 (1986).
[2]. Bloch, A., Dutschman, G., Currie, B.L., et al. Preparation and biological activity of various 3-deazapyrimidines and related nucleosides. J. Med. Chem. 16(3), 294-297 (1973).
[3]. Raynal, N.J.-M., Momparler, L.F., Rivard, G.E., et al. 3-Deazauridine enhances the antileukemic action of 5-aza-2'-deoxycytidine and targets drug-resistance due to deficiency in deoxycytidine kinase. Leuk. Res.35(1),110-118(2011)。

Chemical Properties

Cas No. 23205-42-7 SDF
同義語 NSC 126849
Chemical Name 4-hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone
Canonical SMILES O=C(C=C(O)C=C1)N1[C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2
Formula C10H13NO6 M.Wt 243.2
溶解度 10mg/mL in DMSO, 16mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.1118 mL 20.5592 mL 41.1184 mL
5 mM 0.8224 mL 4.1118 mL 8.2237 mL
10 mM 0.4112 mL 2.0559 mL 4.1118 mL
  • モルアリティ計算機

  • 希釈計算機

質量
=
濃度
x
容積
x
MW*
 
 
 
**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for 3-Deazauridine

Average Rating: 5 ★★★★★ (Based on Reviews and 4 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for 3-Deazauridine

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.