(32-Carbonyl)-RMC-5552 |
| カタログ番号GC63524 |
(32-カルボニル)-RMC-5552 は強力な mTOR 阻害剤です。 (32-カルボニル)-RMC-5552 は、mTORC1 および mTORC2 基質 (p-P70S6K-(T389)、p-4E-BP1-(T37/36)、および p-AKT1/2/3-(S473)) のリン酸化を阻害します。それぞれ、> 9、> 9、および 8 ～ 9 の pIC50 (特許 WO2019212990A1、実施例 2)。
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Cas No.: 2382768-55-8
Sample solution is provided at 25 µL, 10mM.
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(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2)[1].
[1]. Jennifer PITZEN, et al. C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors. WO2019212990A1.
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