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3β-hydroxy-5-Cholestenoic Acid (Synonyms: 3β-hydroxy-5-CA, Cholesterol-26-carboxylic Acid)

カタログ番号GC18817

3β-ヒドロキシ-5コレステノ酸は、コレステロールがシトクロムP450(CYP)アイソメラーであるCYP27A1によって代謝されたときに形成される活性代謝物です。

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3β-hydroxy-5-Cholestenoic Acid 化学構造

Cas No.: 6561-58-6

サイズ 価格 在庫数 個数
500μg
$258.00
在庫あり
1mg
$487.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Description of 3β-hydroxy-5-Cholestenoic Acid

3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3β-hydroxy-5-Cholestenoic acid is a modulator of γ-secretase that decreases amyloid β (1-42) peptide (Aβ42; EC50 = 250 nM) and increases Aβ38 levels with no effect on total Aβ in CHO2B7 cells. It decreases endogenous murine Aβ42 production by 60 and 75% in mouse postnatal neuron-glia cultures at concentrations of 3 and 10 μM, respectively.

Chemical Properties of 3β-hydroxy-5-Cholestenoic Acid

Cas No. 6561-58-6 SDF
同義語 3β-hydroxy-5-CA, Cholesterol-26-carboxylic Acid
Chemical Name (3β)-3-hydroxy-cholest-5-en-26-oic acid
Canonical SMILES [H][C@]12[C@@]([C@@](CC[C@]3([H])[C@H](C)CCCC(C)C(O)=O)([H])[C@]3(C)CC2)([H])CC=C4C[C@@H](O)CC[C@@]41C
Formula C27H44O3 M.Wt 416.6
溶解度 Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 3β-hydroxy-5-Cholestenoic Acid

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4004 mL 12.0019 mL 24.0038 mL
5 mM 0.4801 mL 2.4004 mL 4.8008 mL
10 mM 0.24 mL 1.2002 mL 2.4004 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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