(3S,5S)-Atorvastatin (sodium salt) |
カタログ番号GC13751 |
アトルバスタチン、HMG-CoA還元酵素阻害剤のネガティブコントロール
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1428118-38-0
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
アトルバスタチンは4つの光学異性体が存在します。 (3R, 5R)-アトルバスタチンエナンチオマーは、HMG-CoA還元酵素に対する最大の活性を示します。 (3S,5S)-アトルバスタチンは、ほとんどまたは全くHMG-CoA還元酵素を阻害しないアトルバスタチンのエナンチオマーです[1]。 アトルバスタチンは、内因性コレステロール合成を抑制することにより血漿コレステロール値を低下させることが示唆されている合成的なHMG-CoA還元酵素阻害剤です。 アトルバスタチンはまた、未だ証明されていない機序により三油脂値も低下させます[2]。 高コレステロール血症患者での様々な試験では、アトルバスタチンは総コレステロール、apolipoprotein B、LDL-コレステロールおよび三油脂値の減少を引き起こしました。 初発高コレステロール血症患者では、アトルバ スタチンとコレスティポールの併用は、アトルバスタチン単剤療法よりもLDL-コレステロール値を有意に低下させ、三油脂値の減少は小さいです[2]。
References:
[1] Kocarek T A, Dahn M S, Cai H, et al. Regulation of CYP2B6 and CYP3A expression by hydroxymethylglutaryl coenzyme A inhibitors in primary cultured human hepatocytes[J]. Drug Metabolism and Disposition, 2002, 30(12): 1400-1405.
[2] Lea A P, McTavish D. Atorvastatin[J]. Drugs, 1997, 53(5): 828-847.
Cas No. | 1428118-38-0 | SDF | |
Chemical Name | 2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, monosodium salt | ||
Canonical SMILES | O=C(C1=C(C(C)C)N(CC[C@H](O)C[C@H](O)CC([O-])=O)C(C2=CC=C(F)C=C2)=C1C3=CC=CC=C3)NC4=CC=CC=C4.[Na+] | ||
Formula | C33H34FN2O5 • Na | M.Wt | 580.6 |
溶解度 | ≤0.5mg/ml in ethanol;15mg/ml in DMSO;25mg/ml in dimethyl formamide | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 1.7224 mL | 8.6118 mL | 17.2236 mL |
5 mM | 0.3445 mL | 1.7224 mL | 3.4447 mL |
10 mM | 0.1722 mL | 0.8612 mL | 1.7224 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
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