ホーム>>Signaling Pathways>> PI3K/Akt/mTOR Signaling>> CK2>>4,5,6,7-Tetrabromobenzimidazole

4,5,6,7-Tetrabromobenzimidazole (Synonyms: Casein Kinase II Inhibitor XII,TBBz)

カタログ番号GC16960

4,5,6,7-テトラブロモベンズイミダゾールは、選択的で ATP と競合する CK2 (カゼインキナーゼ 2) 阻害剤です。

Products are for research use only. Not for human use. We do not sell to patients.

4,5,6,7-Tetrabromobenzimidazole 化学構造

Cas No.: 577779-57-8

サイズ 価格 在庫数 個数
25mg
$239.00
在庫あり
250mg
$1,669.00
在庫あり

Tel:(909) 407-4943 Email: sales@glpbio.com

顧客レビュー

カスタマーレビューに基づきます。

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

View current batch:

Background

Ki: 0.5-1 μM

4,5,6,7-Tetrabromobenzimidazole is a CK2 inhibitor.

Casein kinase 2 (CK2), a constitutive protein kinase involved in many signal transduction pathways, is known to be able to negatively regulate apoptosis, and its activity is increased in various proliferating tissues and tumors.

In vitro: Previous study found that like the reported 4,5,6,7-tetrabromobenzotriazole (TBBt), the structurally related 4,5,6,7-tetrabromobenzimidazole (TBBz) was a selective ATP-competitive inhibitor of protein kinase CK2 from various sources including yeast, rat liver, Neurospora crassa and Candida tropicalis, with K(i) values in the range 0.5-1 μM. TBBz was found to virtually inactive vs. PKA, PKC, and a very weak inhibitor of protein kinase CK1. TBBt was noted to be a more effective inhibitor of PK60S than of yeast CK2; by contrast, TBBz was a relatively feeble inhibitor of PK60S, thus more selective than TBBt vs. CK2 in yeast cells. Therefore, similar to TBBt, TBBz could be regarded as an additional lead compound for development of more potent inhibitors of CK2 [1].

In vivo: Up to now, therer is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Zien, P. ,Bretner, M.,Zastapilo, K., et al. Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources. Biochemical and Biophysical Research Communications 306(1), 129-133 (2003).

Chemical Properties

Cas No. 577779-57-8 SDF
同義語 Casein Kinase II Inhibitor XII,TBBz
Chemical Name 4,​5,​6,​7-​tetrabromo-1H-​benzimidazole
Canonical SMILES BrC1=C2C(N=CN2)=C(Br)C(Br)=C1Br
Formula C7H2Br4N2 M.Wt 433.7
溶解度 DMSO: Soluble,Ethanol: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.3057 mL 11.5287 mL 23.0574 mL
5 mM 0.4611 mL 2.3057 mL 4.6115 mL
10 mM 0.2306 mL 1.1529 mL 2.3057 mL
  • モルアリティ計算機

  • 希釈計算機

質量
=
濃度
x
容積
x
MW*
 
 
 
**ストックソリューションを準備する際には、常にバイアルラベルおよび MSDS/CoA(オンラインで利用可能)で掲載された製品のロット固有分子量を使用してください。

計算

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

レビュー

Review for 4,5,6,7-Tetrabromobenzimidazole

Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for 4,5,6,7-Tetrabromobenzimidazole

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.