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4-hydroxy Nonenal Alkyne (Synonyms: Click Tag 4HNE Alkyne)

カタログ番号GC42411

4-ヒドロキシノナール(4-HNE)は、アラキドン酸やリノール酸などのω-6多価不飽和脂肪酸の脂質過酸化反応中に生成される主要なアルデヒドです。

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4-hydroxy Nonenal Alkyne 化学構造

Cas No.: 1011268-23-7

サイズ 価格 在庫数 個数
100μg
$74.00
在庫あり
500μg
$332.00
在庫あり
1mg
$589.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

4-ヒドロキシノナール(4-HNE)は、アラキドン酸やリノール酸などのω-6多価不飽和脂肪酸の脂質過酸化反応によって生成される主要なアルデヒドです。それは、様々な疾患、特に慢性炎症、神経変性疾患、動脈硬化、糖尿病、がんを引き起こす可能性があると考えられています。これはDNAおよびタンパク質を共有結合修飾し、それぞれ遺伝子突然変異および細胞信号伝達の変化を引き起こします。 4-HNE Alkyneは末端アルキンを持つ4-HNEの形式です。このような末端アルキン基は、「クリック・ケミストリー」として知られる連結反応で使用することができます。これらの反応は高い信頼性と特異性を示しました。クリック・ケミストリーは最近までオキシダイズされた脂質の研究にしか適用されていませんでした。

Chemical Properties

Cas No. 1011268-23-7 SDF
同義語 Click Tag 4HNE Alkyne
Canonical SMILES [H]C(/C=C/C(O)CCCC#C)=O
Formula C9H12O2 M.Wt 152.2
溶解度 DMF: 2.5 mg/ml,DMSO: 2 mg/ml,Ethanol: 12.5 mg/ml,PBS (pH 7.2): 5 mg/ml Storage Store at -80°C; protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 6.5703 mL 32.8515 mL 65.703 mL
5 mM 1.3141 mL 6.5703 mL 13.1406 mL
10 mM 0.657 mL 3.2852 mL 6.5703 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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