4-hydroxy Nonenal (Synonyms: 4-HNE) |
カタログ番号GC42410 |
脂質過酸化生成物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 75899-68-2
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
4-ヒドロキシノナールは、アラキドン酸などの酸化されたω-6多価不飽和脂肪酸から派生したリピッド過酸化物生成物です[1] [2]。 4-ヒドロキシノナールは、広くリピッド過酸化のマーカーとして使用されています[2]。 サイトトキシシティ、成長抑制活性、ゲノトキシシティ、およびケモタクティック活性など様々な生物学的活性を示します[1] [2] [3]。 4-ヒドロキシノナールは10〜50μMでプロオキサイダント誘導Ca2 +放出を抑制します。[2]
References:
[1]. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids Free Radical Biology & Medicine 8, 541-543 (1990).
[2]. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes Free Radical Biology & Medicine 11, 81-128 (1991).
[3]. Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal Cancer Research 48, 320-323 (1988).
Cas No. | 75899-68-2 | SDF | |
同義語 | 4-HNE | ||
Chemical Name | (±)-4-hydroxy-2E-nonenal | ||
Canonical SMILES | CCCCCC(O)\C=C\C=O | ||
Formula | C9H16O2 | M.Wt | 156.2 |
溶解度 | 50mg/mL in DMSO, 50mg/mL in DMF, 50mg/mL Ethanol | Storage | -20°C, protect from light. |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 6.402 mL | 32.0102 mL | 64.0205 mL |
5 mM | 1.2804 mL | 6.402 mL | 12.8041 mL |
10 mM | 0.6402 mL | 3.201 mL | 6.402 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
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