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4-hydroxy Nonenal (Synonyms: 4-HNE)

カタログ番号GC42410

脂質過酸化生成物

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4-hydroxy Nonenal 化学構造

Cas No.: 75899-68-2

サイズ 価格 在庫数 個数
10mM (in 1mL DMSO)
$92.00
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1mg
$36.00
在庫あり
5mg
$84.00
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10mg
$133.00
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25mg
$252.00
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50mg
$406.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

4-ヒドロキシノナールは、アラキドン酸などの酸化されたω-6多価不飽和脂肪酸から派生したリピッド過酸化物生成物です[1] [2]。 4-ヒドロキシノナールは、広くリピッド過酸化のマーカーとして使用されています[2]。 サイトトキシシティ、成長抑制活性、ゲノトキシシティ、およびケモタクティック活性など様々な生物学的活性を示します[1] [2] [3]。 4-ヒドロキシノナールは10〜50μMでプロオキサイダント誘導Ca2 +放出を抑制します。[2]

References:
[1]. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids Free Radical Biology & Medicine 8, 541-543 (1990).
[2]. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes Free Radical Biology & Medicine 11, 81-128 (1991).
[3]. Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal Cancer Research 48, 320-323 (1988).

Chemical Properties

Cas No. 75899-68-2 SDF
同義語 4-HNE
Chemical Name (±)-4-hydroxy-2E-nonenal
Canonical SMILES CCCCCC(O)\C=C\C=O
Formula C9H16O2 M.Wt 156.2
溶解度 50mg/mL in DMSO, 50mg/mL in DMF, 50mg/mL Ethanol Storage -20°C, protect from light.
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 6.402 mL 32.0102 mL 64.0205 mL
5 mM 1.2804 mL 6.402 mL 12.8041 mL
10 mM 0.6402 mL 3.201 mL 6.402 mL
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計算

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Related Video

    4-hydroxy Nonenal-GlpBio

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