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(±)-4-hydroxy Propranolol (hydrochloride)

カタログ番号GC16663

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(±)-4-hydroxy Propranolol (hydrochloride) 化学構造

Cas No.: 14133-90-5

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1mg
$63.00
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5mg
$285.00
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10mg
$511.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

IC50: 1.1 μM: inhibits lipid peroxidation in endothelial cells.

(±)-4-hydroxy Propranolol, an active metabolite of propranolol, blocks β1- and β2-adrenergic receptors (β1-ARs, β2-ARs). Also, (±)-4-hydroxy propranolol has antioxidant properties at micromolar concentrations. β1- and β2-ARs, expressed in cardiac myocytes, mediate an increase in contractility by Gs-dependent coupling to adenylyl cyclase.

In vitro: Compared to the control, (±)-4-hydroxy propranolol potently blocked the lipid peroxidation in a concentration-dependent fashion in endothelial cells. When pretreated with (±)-4-hydroxy propranolol at 0.067 to 6.7 μM, the degrees of protection were increased against the glutathione loss in the endothelial cells. Additionally, (±)-4-hydroxy propranolol effectively preserved the loss of cell survival because of the radical stress [1].

In vivo: Rats were injected intravenously with (±)-4-hydroxy propranolol into the femoral vein at 0.1 ml/100 g. (±)-4-hydroxy Propranolol induced an increase in heart rate in a dose-dependent manner in rats depleted of catecholamines, which suggested that (±)-4-hydroxy propranolol had intrinsic sympathomimetic activity. The response of (±)-4-hydroxy propranolol was inhibited when rats were pretreated with 0.5 mg/kg propranolol [2].

References:
[1].  Mak, I. Potent Antioxidant Properties of 4-Hydroxyl-propranolol. Journal of Pharmacology and Experimental Therapeutics. 2003; 308(1): 85-90.
[2].  FITZGERALD, J., & O'DONNELL, S. Pharmacology of 4-hydroxypropranolol, a metabolite of propranolol. British Journal of Pharmacology. 1971; 43(1): 222-235.

Chemical Properties

Cas No. 14133-90-5 SDF
Chemical Name 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol, monohydrochloride
Canonical SMILES OC1=CC=C(OCC(O)CNC(C)C)C2=C1C=CC=C2.Cl
Formula C16H21NO3 • HCl M.Wt 311.8
溶解度 ≤30mg/ml in ethanol;50mg/ml in DMSO;30mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.2072 mL 16.0359 mL 32.0718 mL
5 mM 0.6414 mL 3.2072 mL 6.4144 mL
10 mM 0.3207 mL 1.6036 mL 3.2072 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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