4-oxo Docosahexaenoic Acid (Synonyms: 4-oxo DHA) |
| カタログ番号GC41530 |
4-オキソドコサヘキサエン酸（4-oxo DHA）は、DHAの仮説的な代謝物であり、抗増殖作用とPPARγアゴニスト活性を持っています。
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Cas No.: 845673-74-7
Sample solution is provided at 25 µL, 10mM.
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4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 µM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 µM.
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