5-Aminosalicylic Acid-d7 (Synonyms: 5-ASA-d7, Mesalamine-d7, Mesalazine-d7) |
| カタログ番号GC52413 |
5-アミノサリチル酸の定量化のための内部標準
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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5-Aminosalicylic acid-d7 (5-ASA-d7) is intended for use as an internal standard for the quantification of 5-ASA by GC- or LC-MS. 5-ASA is a non-steroidal anti-inflammatory drug (NSAID) and an active metabolite of sulphasalazine , basalazide , and olsalazine .1 It selectively inhibits COX-2 over COX-1 in isolated human whole blood (IC50s = 61 and 410 µM, respectively). 5-ASA inhibits hemoglobin- and hydrogen peroxide-induced lipid peroxidation in a cell-free assay (IC50 = 50 µM).2 It also inhibits the synthesis of leukotriene B4 in isolated human mucosal cells when used at a concentration of 100 µM.3 Formulations containing 5-ASA have been used in the treatment of inflammatory bowel disease (IBD) and ulcerative colitis.
1.Warner, T.D., Giuliano, F., Vojnovic, I., et al.Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysisProc. Natl. Acad. Sci. USA96(13)7563-7568(1999) 2.Beiranvand, M.A review of the biological and pharmacological activities of mesalazine or 5-aminosalicylic acid (5-ASA): An anti-ulcer and anti-oxidant drugInflammopharmacology29(5)1279-1290(2021) 3.Schmidt, C., Fels, T., Baumeister, B., et al.The effect of 5-aminosalicylate and para-aminosalicylate on the synthesis of prostaglandin E2 and leukotriene B4 in isolated colonic mucosal cellsCurr. Med. Res. Opin.13(7)417-425(1996)
| Cas No. | SDF | ||
| 同義語 | 5-ASA-d7, Mesalamine-d7, Mesalazine-d7 | ||
| Canonical SMILES | [2H]C1=C(C(O[2H])=O)C(O[2H])=C([2H])C([2H])=C1N([2H])[2H] | ||
| Formula | C7D7NO3 | M.Wt | 160.2 |
| 溶解度 | 1M HCl: soluble,DMSO: 4 mg/ml,Ethanol: soluble,Water: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.2422 mL | 31.211 mL | 62.422 mL |
| 5 mM | 1.2484 mL | 6.2422 mL | 12.4844 mL |
| 10 mM | 0.6242 mL | 3.1211 mL | 6.2422 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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