6β-hydroxy Testosterone (Synonyms: 4-Androsten-6β,17β-diol-3-one, 6β, 17β,-Dihydroxyandrost-4-en-3-one) |
| カタログ番号GC19458 |
CYP3A4とCYP3A5は、グルココルチコイドや多くの薬剤および化学発がん物質を含む特定の異物によって誘導されるシトクロムP450酵素です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 62-99-7
Sample solution is provided at 25 µL, 10mM.
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CYP3A4 and CYP3A5 are cytochrome P450 enzymes whose expression is induced by glucocorticoids and certain xenobiotics, including many drugs and chemical carcinogens.1 They mediate the metabolism of xenobiotics as well as certain endobiotics, including steroid hormones.2
6β-hydroxy Testosterone is a major metabolite produced from testosterone by the actions of CYP3A4 and CYP3A5, accounting for 75-80% of all metabolites formed from testosterone.2,3 The biological effects of 6β-hydroxy testosterone have been poorly studied.
Reference:
1. Cooper, B.W., Cho, T.M., Thompson, P.M., et al. Phthalate induction of CYP3A4 is dependent on glucocorticoid regulation of PXR expression Toxicological Sciences 103(2), 268-277 (2008).
2. Draper, A.J., Madan, A., Smith, K., et al. Development of a non-high pressure liquid chromatography assay to determine testosterone hydroxylase (CYP3A) activity in human liver microsomes Drug Metabolism and Disposition 26(4), 299-304 (1998).
3. Capdevila, J.H., Karara, A., Waxman, D.J., et al. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase The Journal of Biological Chemisty 265, 10865-10871 (1990).
| Cas No. | 62-99-7 | SDF | |
| 同義語 | 4-Androsten-6β,17β-diol-3-one, 6β, 17β,-Dihydroxyandrost-4-en-3-one | ||
| Chemical Name | 6β,17β-androst-4-en-3-one | ||
| Canonical SMILES | C[C@@]12[C@](CC[C@@H]2O)([H])[C@]3([H])C[C@@H](O)C4=CC(CC[C@]4(C)[C@@]3([H])CC1)=O | ||
| Formula | C19H28O3 | M.Wt | 304.4 |
| 溶解度 | 1mg/mL in acetonitrile, or in methanol, or in ethanol | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2852 mL | 16.4258 mL | 32.8515 mL |
| 5 mM | 0.657 mL | 3.2852 mL | 6.5703 mL |
| 10 mM | 0.3285 mL | 1.6426 mL | 3.2852 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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