7-Ketodeoxycholic acid (Synonyms: 5β-Cholanic Acid-3α,12α-diol-7-one, 7-keto DCA) |
| カタログ番号GC55814 |
7-Ketodeoxycholic acid is a bile acid derivative that is a metabolite of bile acid in Clostridium absonum. It can also be converted by Lactobacillus and Bifidobacterium under certain conditions.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 911-40-0
Sample solution is provided at 25 µL, 10mM.
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7-Ketodeoxycholic acid is a bile acid derivative that is a metabolite of bile acid in Clostridium absonum. It can also be converted by Lactobacillus and Bifidobacterium under certain conditions[1, 2]. Bile acids are natural steroid amphiphilic compounds formed by cholesterol oxidation in the liver and play a vital role in regulating lipid metabolism[3]. 7-Ketodeoxycholic acid levels are increased in the liver tissue of ethanol-induced alcoholic liver disease (ALD) mice[4]. Patients with non-alcoholic steatohepatitis (NASH) have higher levels of 7-Ketodeoxycholic acid in their plasma[5]. Resistant starch (LRS) can promote the excretion of 7-Ketodeoxycholic acid in hyperlipidemic rats[6].
References:
[1] Sutherland J D, Macdonald I A. The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum[J]. Journal of lipid research, 1982, 23(5): 726-732.
[2] Takahashi T, Morotomi M. Absence of cholic acid 7α-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium[J]. Journal of Dairy Science, 1994, 77(11): 3275-3286.
[3] Li T, Chiang J Y L. Regulation of bile acid and cholesterol metabolism by PPARs[J]. PPAR research, 2009, 2009(1): 501739.
[4] Charkoftaki G, Tan W Y, Berrios-Carcamo P, et al. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice[J]. 2022.
[5] Nimer N. Mass Spectrometry as Discovery Platform for Candidate Metabolite of Non-Alcoholic Steatohepatitis (NASH)[D]. Cleveland State University, 2020.
[6] Lei S, Liu L, Yue P, et al. Lotus seed resistant starch decreases the blood lipid and regulates the serum bile acids profiles in hyperlipidemic rats[J]. Journal of Functional Foods, 2022, 92: 105040.
| Cas No. | 911-40-0 | SDF | |
| 同義語 | 5β-Cholanic Acid-3α,12α-diol-7-one, 7-keto DCA | ||
| Formula | C24H38O5 | M.Wt | 406.56 |
| 溶解度 | DMSO : 100 mg/mL (245.97 mM; Need ultrasonic) | Storage | Store at -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.4597 mL | 12.2983 mL | 24.5966 mL |
| 5 mM | 0.4919 mL | 2.4597 mL | 4.9193 mL |
| 10 mM | 0.246 mL | 1.2298 mL | 2.4597 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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