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8-Chloro-cAMP

カタログ番号GC64460

8-クロロ-cAMP は、成長停止を誘導し、cAMP 依存性 PKA 活性を調節する cAMP 類似体です。 8-クロロ-cAMP には抗がん作用があります。

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8-Chloro-cAMP 化学構造

Cas No.: 41941-56-4

サイズ 価格 在庫数 個数
5 mg
$1,242.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

8-Chloro-cAMP is a cAMP analogue that induces growth arrest, and modulates cAMP-dependent PKA activity. 8-Chloro-cAMP has anticancer activity[1].

8-Chloro-cAMP markedly inhibits vascular smooth muscle cell (VSMC) proliferation in vitro, reduces protein kinase A (PKA) RIα subunit expression, and induces PKA RIIβ subunit expression[1].

In rat bearing balloon injury, 8-Chloro-cAMP (12 mg/kg) reduces, in a dose-dependent manner, neointimal area and neointima/media ratio after balloon injury. 8-Chloro-cAMP shows a reduction of proliferative activity of VSMCs in vivo[1].

[1]. C Indolfi, et al. 8-chloro-cAMP inhibits smooth muscle cell proliferation in vitro and neointima formation induced by balloon injury in vivo. J Am Coll Cardiol. 2000 Jul;36(1):288-93.

Chemical Properties

Cas No. 41941-56-4 SDF Download SDF
Formula C10H11ClN5O6P M.Wt 363.65
溶解度 Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.7499 mL 13.7495 mL 27.499 mL
5 mM 0.55 mL 2.7499 mL 5.4998 mL
10 mM 0.275 mL 1.3749 mL 2.7499 mL
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