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α-CEHC (Synonyms: γTocopherol Metabolite, GTM, 2,7,8trimethyl2(βCarboxyEthyl)6Hydroxychroman)

カタログ番号GC11123

δ-トコフェロールの主要代謝物

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α-CEHC 化学構造

Cas No.: 4072-32-6

サイズ 価格 在庫数 個数
1mg
$26.00
在庫あり
5mg
$117.00
在庫あり
10mg
$208.00
在庫あり
25mg
$455.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

ビタミンE抗酸化活性を持つ分子には、4種類のトコフェロール(α、β、δ、γ)と4種類のトコトリエノール(α、β、δ、γ)が含まれます。α-トコフェロールは体内で主要な脂溶性抗酸化物質であり、脂質過酸化反応から保護します。α-CEHCはビタミンE補充後のα-トコフェロールの主要な尿中代謝産物です。人間血清中のα-CEHC濃度は5〜10 pmol/mlの範囲にありますが、RRR-α-トコフェロール補充により200 pmol/mlまで有意に増加します。血液中循環しているα-CEHCの約1/3はグルクロン酸共役体として存在します。 α-tocopherol/g全リピドプラズマあたり7〜9μmol以上の閾値濃度を超えた場合に限り、α-CEHCが排泄されました。したがって、α-CEHCの排泄は最適なビタミンE摂取量を示すマーカーと考えられます。

Chemical Properties

Cas No. 4072-32-6 SDF
同義語 γTocopherol Metabolite, GTM, 2,7,8trimethyl2(βCarboxyEthyl)6Hydroxychroman
Canonical SMILES CC1=C(OC(CCC(O)=O)(C)CC2)C2=C(C)C(O)=C1C
Formula C16H22O4 M.Wt 278.3
溶解度 DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2)(1:1): .25 mg/ml,Ethanol: 10 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL
10 mM 0.3593 mL 1.7966 mL 3.5932 mL
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計算

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 35 reference(s) in Google Scholar.)

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