α-CEHC (Synonyms: γTocopherol Metabolite, GTM, 2,7,8trimethyl2(βCarboxyEthyl)6Hydroxychroman) |
カタログ番号GC11123 |
δ-トコフェロールの主要代謝物
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4072-32-6
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
ビタミンE抗酸化活性を持つ分子には、4種類のトコフェロール(α、β、δ、γ)と4種類のトコトリエノール(α、β、δ、γ)が含まれます。α-トコフェロールは体内で主要な脂溶性抗酸化物質であり、脂質過酸化反応から保護します。α-CEHCはビタミンE補充後のα-トコフェロールの主要な尿中代謝産物です。人間血清中のα-CEHC濃度は5〜10 pmol/mlの範囲にありますが、RRR-α-トコフェロール補充により200 pmol/mlまで有意に増加します。血液中循環しているα-CEHCの約1/3はグルクロン酸共役体として存在します。 α-tocopherol/g全リピドプラズマあたり7〜9μmol以上の閾値濃度を超えた場合に限り、α-CEHCが排泄されました。したがって、α-CEHCの排泄は最適なビタミンE摂取量を示すマーカーと考えられます。
Cas No. | 4072-32-6 | SDF | |
同義語 | γTocopherol Metabolite, GTM, 2,7,8trimethyl2(βCarboxyEthyl)6Hydroxychroman | ||
Canonical SMILES | CC1=C(OC(CCC(O)=O)(C)CC2)C2=C(C)C(O)=C1C | ||
Formula | C16H22O4 | M.Wt | 278.3 |
溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2)(1:1): .25 mg/ml,Ethanol: 10 mg/ml | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 3.5932 mL | 17.9662 mL | 35.9324 mL |
5 mM | 0.7186 mL | 3.5932 mL | 7.1865 mL |
10 mM | 0.3593 mL | 1.7966 mL | 3.5932 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 35 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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