α-Ecdysone |
| カタログ番号GC45204 |
α-エキジソンは、昆虫の脱皮に関与するエキジステロイドホルモンである20-ヒドロキシエキジソンのプロホルモンです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 3604-87-3
Sample solution is provided at 25 µL, 10mM.
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Ecdysone (α-ecdysone) is a steroidal molting hormone that exists in insects and plants and activates mineralocorticoid receptor (MR), leading to glomerular diseases[1]. Ecdysone is also an essential regulator of developmental transitions, including molting and metamorphosis in insects[2].
Ecdysone (0.1, 1, 5, and 10μM for 24h) significantly downregulated the key proteins of the TLR-pathways such as TLR-4, MYD88, IKK-α and IKK-ϒ in RAW 264.7 cells. These proteins were associated with inflammation. Therefore, ecdysone could suppress the TLR pathway to protect cells from inflammation[3].
Ecdysone treatment (6µg/g/d) resulted in evident mesangial deposition of fibronectin and significant reduction in the expression of podocyte-specific molecules such as synaptophysin in male C57BL/6 mice. These phenomena indicated that ecdysone treatment caused glomerulosclerosis and podocyte injury[4].
References:
[1]. Lu M, Wang P, Ge Y, Dworkin L, Brem A, Liu Z, et al. Activation of mineralocorticoid receptor by ecdysone, an adaptogenic and anabolic ecdysteroid, promotes glomerular injury and proteinuria involving overactive GSK3beta pathway signaling. Sci Rep. 2018;8(1):12225. Epub 20180815. doi: 10.1038/s41598-018-29483-7. PubMed PMID: 30111886.
[2]. Xu T, Jiang X, Denton D, Kumar S. Ecdysone controlled cell and tissue deletion. Cell Death Differ. 2020;27(1):1-14. Epub 20191119. doi: 10.1038/s41418-019-0456-9. PubMed PMID: 31745213.
[3].Bhardwaj M, Mamadalieva NZ, Chauhan AK, Kang SC. alpha-Ecdysone suppresses inflammatory responses via the Nrf2 pathway in lipopolysaccharide-stimulated RAW 264.7 cells. Int Immunopharmacol. 2019;73:405-13. Epub 20190529. doi:10.1016/j.intimp.2019.05.038. PubMed PMID: 31152978.
[4]. Lu M, Wang P, Zhou S, Flickinger B, Malhotra D, Ge Y, et al. Ecdysone Elicits Chronic Renal Impairment via Mineralocorticoid-Like Pathogenic Activities. Cell Physiol Biochem. 2018;49(4):1633-45. Epub 20180918. doi: 10.1159/000493499. PubMed PMID: 30227391.
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