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α-hydroxy Farnesyl Phosphonic Acid (Synonyms: Hydroxyfarnesyl Phosphate)

カタログ番号GC45207

α-ヒドロキシファルネシルホスホン酸は、ファルネシルピロリン酸の非加水分解アナログであり、ファルネシルトランスフェラーゼ(FTase)の競合阻害剤として作用します。

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α-hydroxy Farnesyl Phosphonic Acid 化学構造

Cas No.: 148796-53-6

サイズ 価格 在庫数 個数
1mg
$170.00
在庫あり
5mg
$763.00
在庫あり
10mg
$1,358.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

α-ヒドロキシファルネシルホスホン酸は、ファルネシルピロリン酸の非加水分解アナログであり、ファルネシルトランスフェラーゼ(FTase)の競合阻害剤として作用します。 1μM以上の濃度では、α-ヒドロキシファルネシルホスホン酸はHa-ras変異体を持つNIH3T3細胞内でRasの処理を抑制します。

Chemical Properties

Cas No. 148796-53-6 SDF
同義語 Hydroxyfarnesyl Phosphate
Canonical SMILES C/C(=C\CC\C(=C\C(O)P(=O)(O)O)\C)/CCC=C(C)C
Formula C15H27O4P M.Wt 302.4
溶解度 10 mM Na2CO3: freely soluble,ETOH: >25 mg/ml,PBS pH 7.2: <25 µ g/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 3.3069 mL 16.5344 mL 33.0688 mL
5 mM 0.6614 mL 3.3069 mL 6.6138 mL
10 mM 0.3307 mL 1.6534 mL 3.3069 mL
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計算

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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