α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) (Synonyms: α-Melanocyte-stimulating Hormone, Ac-SYSMEHFRWGKPV-NH2) |
| カタログ番号GC48292 |
α-MSH (α-メラノサイト刺激ホルモン) 内因性神経ペプチドである TFA は、抗炎症作用と解熱作用を持つ内因性メラノコルチン受容体 4 (MC4R) アゴニストです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 171869-93-5
Sample solution is provided at 25 µL, 10mM.
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α-Melanocyte-stimulating hormone (α-MSH) is a 13-amino acid peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland, as well as in keratinocytes, astrocytes, monocytes, and gastrointestinal cells.1 It is an agonist of melanocortin receptor 3 (MC3R) and MC4R that induces cAMP production in Hepa cells expressing the human receptors (EC50s = 0.16 and 56 nM, respectively).2 α-MSH (100 pM) reduces S. aureus colony formation and C. albicans germ tube formation in vitro.3 It inhibits endotoxin-, ceramide-, TNF-α-, or okadaic acid-induced activation of NF-κB in U937 cells.1 α-MSH reduces IL-6- or TNF-α-induced ear edema in mice.4 It also prevents the development of adjuvant-induced arthritis in rats and increases survival in a mouse model of septic shock. Increased plasma levels of α-MSH are positively correlated with delayed disease progression and reduced death in patients with HIV.1
1.Catania, A., Airaghi, L., Colombo, G., et al.α-melanocyte-stimulating hormone in normal human physiology and disease statesTrends Endocrinol. Metab.11(8)304-308(2000) 2.Miwa, H., Gantz, I., Konda, Y., et al.Structural determinants of the melanocortin peptides required for activation of melanocortin-3 and melanocortin-4 receptorsJ. Pharmacol. Exp. Ther.273(1)367-372(1995) 3.Cutuli, M., Cristiani, S., Lipton, J.M., et al.Antimicrobial effects of a-MSH peptidesJ. Leukoc. Biol.67(2)233-239(2000) 4.Lipton, J.M., Ceriani, G., Macaluso, A., et al.Antiiinflammatory effect of the neuropeptide a-MSH in acute, chronic, and systemic inflammationAnn. N.Y. Acad. Sci.25(741)137-148(1994)
| Cas No. | 171869-93-5 | SDF | |
| 同義語 | α-Melanocyte-stimulating Hormone, Ac-SYSMEHFRWGKPV-NH2 | ||
| Canonical SMILES | O=C(NCC(N[C@@H](CCCCN)C(N(CCC1)[C@@H]1C(N[C@H](C(N)=O)C(C)C)=O)=O)=O)[C@@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CCSC)NC([C@H](CO)NC([C@@H](NC([C@H](CO)NC(C)=O)=O)CC(C=C2)=CC=C2O)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)=O)CC5=CNC6=CC=CC=C56.FC(F)(C(O)=O)F | ||
| Formula | C77H109N21O19S.XCF3COOH | M.Wt | 1664.9 |
| 溶解度 | DMF: 10mg/mL,DMSO: 25mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.6006 mL | 3.0032 mL | 6.0064 mL |
| 5 mM | 0.1201 mL | 0.6006 mL | 1.2013 mL |
| 10 mM | 0.0601 mL | 0.3003 mL | 0.6006 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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