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α-Muricholic Acid-d4 (Synonyms: ω-MCA-d4)

カタログ番号GC49008

α-ムリコール酸の定量化のための内部標準

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α-Muricholic Acid-d4 化学構造

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1 mg
$342.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

α-Muricholic acid-d4は、GC-またはLC-MSによるα-muricholic acidの定量化のための内部標準として使用することを意図しています。 α-Muricholic酸はマウス特異的な一次胆汁酸です。1,2大豆タンパク質の食事投与により、高脂肪ダイエット誘発性肥満マウスの糞便中のα-muricholic酸レベルが減少し、二次胆汁酸の主要生産者であるClostridium cluster XIVa群菌数が増加することと相関します。3高脂肪から低脂肪ダイエットに切り替えたマウスでは、血漿、肝臓、筋肉中のα-muricholic酸レベルが増加します。4

1. Eyssen, H.J., Parmentier, G.G., and Mertens, J.A. (1976). Sulfate bile acids in germ-free and conventional mice. Eur. J. Biochem., 66(3), 507-514. 2. Uehara, T., Xi Peng, X., Bennett, B., et al. (2004). c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.Transplantation78(3)324-332. 3. Watanabe, K., Igarashi, M., Li, X., et al.(2018). Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.PLoS One13(8)e0202083. 4.La Frano,M.R,Hernandez-Carretero,A.Weber,N.et al.(2017).Diet-induced obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6J mice.Nutr.Res46:11-21

Chemical Properties

Cas No. N/A SDF
同義語 ω-MCA-d4
Canonical SMILES C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@@H](O)[C@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C
Formula C24H36D4O5 M.Wt 412.6
溶解度 DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.4237 mL 12.1183 mL 24.2365 mL
5 mM 0.4847 mL 2.4237 mL 4.8473 mL
10 mM 0.2424 mL 1.2118 mL 2.4237 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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