α-Truxillic Acid (Synonyms: Gratissimic Acid) |
| カタログ番号GC45224 |
α-トルキシル酸は、抗炎症活性を持つα-trans-桂皮酸の 2 つの分子の二量体化によって形成されます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 490-20-0
Sample solution is provided at 25 µL, 10mM.
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α-Truxillic acid can be formed by the dimerization of two molecules of α-trans-cinnamic acid. [1] It is related to incarvillateine, a natural antinociceptive compound derived from the Asian herb I. sinensis. [2] α-Truxillic acid and some of its derivatives significantly block inflammatory pain while having little effect on neurogenic pain, as indicated by the formalin test in mice. [2] [3] Related compounds, like SB-FI-26 , bind fatty acid binding protein 5 (FABP5). [4] This may be related to pain suppression, since FABP5 acts as a transporter of the endocannabinoid anandamide. [5] While certain derivatives of α-truxillic acid can directly activate peroxisome proliferator-activated receptor γ, α-truxillic acid has no such activity. [6]
Reference:
[1]. Benedict, J.B., and Coppens, P. Kinetics of the single-crystal to single-crystal two-photon photodimerization of α-trans-cinnamic acid to α-truxillic acid. J.Phys.Chem.A. 113(13), 3116-3120 (2009).
[2]. Chi, Y.M., Nakamura, M., Yoshizawa, T., et al. Anti-inflammatory activities of α-truxillic acid derivatives and their monomer components. Biological and Pharmaceutical Bullentin 28(9), 1776-1778 (2005).
[3]. Chi, Y.M., Nakamura, M., Zhao, X.Y., et al. Antinociceptive activities of α-truxillic acid and β-truxillic acid derivatives. Biological and Pharmaceutical Bullentin 29(3), 580-584 (2006).
[4]. Berger, W.T., Ralph, B.P., Kaczocha, M., et al. Targeting fatty acid binding protein (FABP) anandamide transporters - a novel strategy for development of anti-inflammatory and anti-nociceptive drugs. PLoS One 7(12), (2012).
[5]. Kaczocha, M., Glaser, S.T., and Deutsch, D.G. Identification of intracellular carriers for the endocannabinoid anandamide. Proceedings of the National Academy of Sciences of the United States of America 106(15), 6375-6380 (2009).
[6]. Steri, R., Rupp, M., Proschak, E., et al. Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators. Bioorganic & Medicinal Chemistry Letters 20(9), 2920-2923 (2010).
| Cas No. | 490-20-0 | SDF | |
| 同義語 | Gratissimic Acid | ||
| Chemical Name | (1α,2α,3β,4β)-2,4-diphenyl-1,3-cyclobutanedicarboxylic acid | ||
| Canonical SMILES | OC([C@H]1[C@H](C2=CC=CC=C2)[C@H](C(O)=O)[C@H]1C3=CC=CC=C3)=O | ||
| Formula | C18H16O4 | M.Wt | 296.3 |
| 溶解度 | 20mg/mL in DMSO, 16mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.375 mL | 16.8748 mL | 33.7496 mL |
| 5 mM | 0.675 mL | 3.375 mL | 6.7499 mL |
| 10 mM | 0.3375 mL | 1.6875 mL | 3.375 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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