β-Amyrone (Synonyms: β-Amyron) |
| カタログ番号GC66340 |
β-Amyrone (&7#946;-Amyron) は、COX-2 の発現を阻害することにより抗炎症活性を持つトリテルペン化合物です。 β-アミロンには抗真菌活性があり、チクングニアウイルスに対する抗ウイルス活性もあります. β-アミロンは α-グルコシダーゼおよびアセチルコリンエステラーゼ (AChE) 活性も阻害します。 β-アミロンは、炎症、感染症、肥満などの病気の研究に使用できます.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 638-97-1
Sample solution is provided at 25 µL, 10mM.
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β-Amyrone (β-Amyron) is a triterpene compound which has anti-inflammatory activity through inhibiting the expression of COX-2. β-Amyrone has antifungal activity , as well as antiviral activity against Chikungunya virus. β-Amyrone also inhibits α-glucosidase and acetylcholinesterase (AChE) activity. β-Amyrone can be used in the research of disease like inflammation, infection, and obesity[1][2][3][4].
β-Amyrone (1.25-10 μg/mL, 24 h) inhibits on NO? production in LPS-stimulated J774 cells, with an IC50 value of 4.61 μg/mL, and has no obvious effect on cell viability[1].
β-Amyrone (10 μg/mL, 24 h) inhibits IL-6, IL-10 levels, and COX-2 expression in LPS-stimulated J774 cells[1].
β-Amyrone (0-235 μM, 7days) has antiviral activity in Vero cells against Chikungunya virus (CHIKV), with EC50 value of 86 uM[2].
β-Amyrone inhibits α-glucosidase, acetylcholinesterase (AChE) and fungal activity with IC50 values of 25 μM, 23 μM and 8 μg/mL, respectively[4].
Western Blot Analysis[1]
| Cell Line: | LPS (1 μg/mL)-stimulated J774 cells |
| Concentration: | 2.5, 5, 10 μg/mL |
| Incubation Time: | 24 h |
| Result: | Inhibited COX-2 expression in a concentration-dependent manner (approximately 90% reduction at 5 or 10 μg/ mL). |
β-Amyrone (local administration on ear, 0.1-0.6 mg/kg, a single dose) inhibits ear edema formation in phenol-induced edema mice[1].
| Animal Model: | Ear phenol-induced edema in Balb C mice[1] |
| Dosage: | 0.1, 0.3, 0.6 mg/kg, a single dose |
| Administration: | Local administration (20 ??L solution) on ear |
| Result: | Inhibited ear edema formation in a dose-related manner (47% inhibition at the dose of 0.6mg/kg). |
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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