β-Elemonic Acid (Synonyms: Elemadienonic Acid, 3-Oxotirucallenoic Acid, 3-oxo Tirucallic Acid) |
| カタログ番号GC41623 |
β-エレモン酸は、ボスウェリア パピリフェラから分離されたトリテルペンです。
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Cas No.: 28282-25-9
Sample solution is provided at 25 µL, 10mM.
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β-Elemonic acid is a triterpene isolated from Boswellia (Burseraceae) that exhibits anticancer activity. It inhibits growth of non-small cell lung cancer (NSCLC) A549 cells (IC50 = 6.92 µM) in vitro. β-Elemonic acid induces apoptosis and cytotoxicity in A549 cells in a dose-dependent manner but has no effect on normal epithelial WI-38 cells. It inhibits phosphorylation of p42/44, MAPK/JNK, and p38 and induces production of reactive oxygen species (ROS) and COX-2 expression in vitro. β-Elemonic acid also inhibits prolyl endopeptidase (IC50 = 39.74 µM) in vitro.
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