β-Muricholic Acid (Synonyms: 5β-Cholanic Acid-3α,6β,7β-triol, β-MCA) |
| カタログ番号GC40719 |
マウス特異的なプライマリ胆汁酸
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2393-59-1
Sample solution is provided at 25 µL, 10mM.
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β-Muricholic acid (β-MCA) is a murine-specific primary bile acid.[1],[2] Dietary administration of β-MCA reduces HMG-CoA reductase activity in liver microsomes from mice fed a high cholesterol and cholic acid diet.[3] Dietary administration of β-MCA also dissolves 100% of gallstones in a gallstone-susceptible mouse model of diet-induced cholesterol gallstones.[4]
Reference:
[1]. Eyssen, H.J., Parmentier, G.G., and Mertens, J.A. Sulfate bile acids in germ-free and conventional mice. Eur. J. Biochem. 66(3), 507-514 (1976).
[2]. Wahlström, A., Sayin, S.I., Marschall, H.-I., et al. Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24(1), 41-50 (2016).
[3]. Fujino, Y., Nakayama, K., Yoshimura, K., et al. Suppression of hepatic HMG-CoA reductase activity by β-muricholic acid in mice fed a diet containing cholesterol and cholic acid. Jpn. J. Pharmacol. 46(4), 421-423 (1988).
[4]. Wang, D.Q.-H., and Tazuma, S. Effect of β-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. J. Lipid. Res. 43(11), 1960-1968 (2002).
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