γ1-MSH (human, mouse, rat, bovine) (acetate) (Synonyms: γ1-Melanocyte-stimulating Hormone) |
| カタログ番号GC92102 |
γ1-MSH (human, mouse, rat, bovine) (acetate)はペプチドホルモンであり、下垂体中の前皮黒皮質（POMC）を翻訳して加工して産生する。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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γ1-Melanocyte-stimulating hormone (γ1-MSH) is a peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland.1 It selectively binds to melanocortin receptor 1 (MC1R) and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 ?M, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 ?M).2,3 γ1-MSH (10 ?M) inhibits contractions induced by the neuropeptide FMRF-amide in isolated M. edulis catch muscle.4 Intracisternal administration of γ1-MSH (0.3 nmol/animal) increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice.5 γ1-MSH (0.01 nmol/animal) also inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo.2
References:
[1]. Rubakhin, S.S., Churchill, J.D., Greenough, W.T., et al.Profiling signaling peptides in single mammalian cells using mass spectrometryAnal. Chem.78(20)7267-7272(2006).
[2]. Muceniece, R., Zvejniece, L., Liepinsh, E., et al.The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation modelPeptides27(6)1443-1450(2006).
[3]. Oki, S., Nakao, K., Nakai, Y., et al.'γ-MSH' fragments from ACTH-beta-LPH precursor have an affinity for opiate receptorsEur. J. Pharmacol.64(2-3)161-164(1980).
[4]. Muneoka, Y., and Saitoh, H.Pharmacology of FMRFamide in Mytilus catch muscleComp. Biochem. Physiol. C Comp. Pharmacol. Toxicol.85(1)207-214(1986).
[5]. Klusa, V., Germane, S., Svirskis, S., et al.The γ2-MSH peptide mediates a central analgesic effect via a GABA-ergic mechanism that is independent from activation of melanocortin receptorsNeuropeptides35(1)50-57(2001).
| Cas No. | SDF | ||
| 同義語 | γ1-Melanocyte-stimulating Hormone | ||
| Chemical Name | (3S,6S,9S,12S,15S,21S,24S,27S)-15-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-27-amino-3-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)carbamoyl)-12-benzyl-9-(3-guanidinopropyl)-28-(4-hydroxyphenyl)-24-isopropyl-21-(2-(methylthio)ethyl)-5,8,11,14,17,20,23,26-octaoxo-4,7,10,13,16,19,22,25-octaazaoctacosanoic acid, acetate | ||
| Canonical SMILES | O=C([C@H](CC1=CNC2=CC=CC=C21)NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@H](CC4=CN=CN4)NC(CNC([C@@H](NC([C@@H](NC([C@H](CC5=CC=C(O)C=C5)N)=O)C(C)C)=O)CCSC)=O)=O)=O)=O)CCCNC(N)=N)=O)N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=CC=C6)C(N)=O)=O)CCCNC(N)=N)=O)CC(O)=O.CC(O)=O | ||
| Formula | C72H97N21O14S ? XC2H4O2 | M.Wt | 1512.8 |
| 溶解度 | DMSO: Sparingly soluble: 1-10 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.661 mL | 3.3051 mL | 6.6103 mL |
| 5 mM | 0.1322 mL | 0.661 mL | 1.3221 mL |
| 10 mM | 0.0661 mL | 0.3305 mL | 0.661 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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