γ-Aminobutyric acid-d6 |
| カタログ番号GC64508 |
γ-アミノ酪酸-d6（4-アミノ酪酸-d6）は、重水素標識されたγ-アミノ酪酸です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 70607-85-1
Sample solution is provided at 25 µL, 10mM.
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γ-Aminobutyric acid-d6 (4-Aminobutyric acid-d6) is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Chen S, et al. Effects of dietary gamma-aminobutyric acid supplementation on the intestinal functions in weaning piglets. Food Funct. 2019 Jan 2.
[3]. Okada R, et al. Gamma-aminobutyric acid (GABA)-mediated neural connections in the Drosophila antennal lobe. J Comp Neurol. 2009 May 1;514(1):74-91.
[4]. Watanabe M, et al. GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol. 2002;213:1-47.
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