δ12-Prostaglandin J2 (Synonyms: Δ12PGJ2) |
| カタログ番号GC41109 |
δ12-プロスタグランジン J2 (δ12-PGJ2) は、さまざまな腫瘍細胞の増殖に対する抗増殖効果を持つシクロペンテノン プロスタグランジン (PG) です。 δ12-プロスタグランジン D2 の天然の脱水生成物であるプロスタグランジン J2 は、カスパーゼ活性化を介して HeLa 細胞のアポトーシスを誘導することができます。
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Cas No.: 87893-54-7
Sample solution is provided at 25 µL, 10mM.
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δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml. δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARγ ligand.
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