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δ12-Prostaglandin J2 (Synonyms: Δ12PGJ2)

カタログ番号GC41109

δ12-プロスタグランジン J2 (δ12-PGJ2) は、さまざまな腫瘍細胞の増殖に対する抗増殖効果を持つシクロペンテノン プロスタグランジン (PG) です。 δ12-プロスタグランジン D2 の天然の脱水生成物であるプロスタグランジン J2 は、カスパーゼ活性化を介して HeLa 細胞のアポトーシスを誘導することができます。

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δ12-Prostaglandin J2 化学構造

Cas No.: 87893-54-7

サイズ 価格 在庫数 個数
100μg
$55.00
在庫あり
500μg
$247.00
在庫あり
1mg
$439.00
在庫あり

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

δ12-PGJ2 is a decomposition product of PGD2 in aqueous media in the presence of albumin. It has antitumor and antiviral activity, inhibiting growth of cultured L1210 cells at with an IC50 value of 0.7 µg/ml. δ12-PGJ2 is present in normal human urine with a 24 hour excretion rate of 50-150 ng. It is also a moderately potent PPARγ ligand.

Chemical Properties

Cas No. 87893-54-7 SDF
同義語 Δ12PGJ2
Canonical SMILES CCCCC[C@H](O)C/C=C([C@@H](C/C=C\CCCC(O)=O)C=C1)/C1=O
Formula C20H30O4 M.Wt 334.5
溶解度 DMF: >100 mg/ml (from PGD2),DMSO: >50 mg/ml (from PGD2),Ethanol: >75 mg/ml (from PGD2),PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-d12, Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.9895 mL 14.9477 mL 29.8954 mL
5 mM 0.5979 mL 2.9895 mL 5.9791 mL
10 mM 0.299 mL 1.4948 mL 2.9895 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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